Genome-edited animals have been made a great contribution to society by providing invaluable resources to industry fields as well as research fields. In this regards, we have been pursing goals for development of novel genome-edited avian lines with high-end genome editing technologies. We are convinced that the invaluable avian lines could be important assets for future society.
The Laboratory of Animal Genetic Engineering has focused its research on
The Laboratory of Stem Cell and Bioevaluation is currently working to (1) develop technology to establish stem cell lines derived from diverse origins and (2) provide standard guidelines for stem cell research by quality evaluation of more than 100 established stem cell lines.
The following are the major research areas: (1) germ-cell-based research, (2) stem cell establishment and quality control, and (3) reprogramming and cell transformation.
Germ cell-based research focuses on enhancing the efficiency of Assisted Reproductive Technology (ART) by establishing mature oocytes from preantral follicles and developing a source technology to establish autologous stem cells from embryos derived from in vitro fertilization or parthenogenetic activation.
This area of research involves developing somatic stem cell isolation techniques from diverse origins and establishing a bioevaluation system for stem cells used for research purposes or in clinical settings.
This research seeks to understand the in vivo microenvironment of stem cells and mimic that in vitro to track the cell transformation process and uncover cellular reprogramming and carcinogenesis procedures.
In the Animal Reproduction and Transgenesis Laboratory, we produce transgenetic animals and establish animal embryonic stem cell lines using artificial insemination (AI), in vitro fertilization (IVF), embryo transfer (ET), somatic cell nucleus transfer (SCNT), etc. based on studies of developmental biology, molecular biology, and cell biology. We also investigate the industrial and medical application of animal product.
Our research group focuses on bioinformatics analyses of sequence data to study molecular-level evolution and the genetics associated with disease. We take an interdisciplinary approach using biology, statistics, mathematics, and informatics. Improvements in next-generation sequencing (NGS) methods have greatly increased the rate of biological data generation. As these data accumulate, our group aims to introduce a new paradigm in genetic breeding by applying the principles of population genetics to domestication genes and polymorphisms, from the perspective of animal biotechnology.